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Breaking New Ground

Research led by Dr. Shane Harding and PhD student Kate MacDonald sheds new light on the role of micronuclei — small structures in cells that contain fragments of genetic material — in response to DNA damage. The team found that different types of stress and DNA damage-inducing treatments affect the ability of micronuclei to initiate inflammatory pathways. This research could ultimately lead to more effective cancer treatments with less side effects.

 
  1. (L-R) Kate MacDonald and Dr. Shane Harding.
  2. Micronuclei are tiny, enclosed structures that contain genetic material.

Predicting Outcomes in Lung Cancer

A research team co-led by Affiliate Scientist Dr. Michael Moran and Senior Scientist Dr. Ming-Sound Tsao, with first author Dr. Shideh Mirhadi, has shown that laboratory models of lung cancer closely mirror the behaviour of human tumours. By extensively studying the genetics and the protein landscape of these tumours, researchers might be able to identify anti-cancer therapies that go beyond targeting single mutations.

 
  1. (L-R) First author Dr. Shideh Mirhadi and Drs. Michael Moran and Ming-Sound Tsao.

New Targets for Blood Cancers

A recent study co-led by Dr. Lina Liu and Dr. Kristin Hope has identified a potential target for a common form of blood cancer known as acute myeloid leukemia (AML). While there have been improvements in recent years, less than a quarter of individuals with AML survive beyond five years of diagnosis. This research could potentially generate new treatments for AML.

 
  1. (L-R) Dr. Lina Liu and Dr. Kristin Hope.
  2. Photo of acute myeloid leukemia (AML) cells under a microscope.

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