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Though born ten years apart, siblings Juliet and Lucas Locke share a strong bond, made even stronger through their mutual diagnosis of Li-Fraumeni Syndrome (LFS). LFS is a rare condition caused by an inherited gene mutation and comes with an almost 100% risk of developing cancer. Their mother, Luana Locke, also has LFS and has already lived through six different cancer diagnoses. Juliet was just 14 when she was diagnosed with leukemia.

Previously, catching early signs of cancer relied on the family making multiple trips to the clinic, which could be very time-consuming, and blood tests could be imprecise.

But now, researchers at The Princess Margaret have pioneered a new way to detect cancer earlier in people with LFS – often even before a tumour becomes visible, or symptoms start. Through an early detection technique known as a “liquid biopsy,” researchers can detect microscopic traces of cancer before it’s visible on an X-ray or CT scan.

That means if a cancer begins to develop, doctors can now catch it much earlier. Knowing where and when the cancer is developing helps the doctors interrupt the tumour’s growth at the molecular level, when the cancer is in its most treatable stage and the patient has the best chance at survival.

This technique may also eventually eliminate the need for frequent scans tests, and at the same time increase the specificity and accuracy of a cancer diagnosis.

“It’s incredible how much they can tell through one blood test,” says Juliet. “We’re so fortunate that this technology exists and that we get to benefit from it.”

“We’re beyond grateful for the team at The Princess Margaret,” adds Lucas. “Regular scans and check-ups are routine when you have LFS, but the ability to predict when and where cancers develop rather than react when one has already developed would be life-changing.”

Thanks to these advancements in early detection, Juliet looks forward to being able to spend as much time as possible with her brother. “My mom lost her brother to cancer, and we see how much that affects her. Hopefully Lucas and I don't have to endure that same fate because of the work that's being done.”


“Early detection is everything to our family. Every time we had to deal with cancer, I knew we were going to be okay.”

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Juliet & Lucas Locke 
Early Cancer Detection Patients 

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