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Research 'Firsts'
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Research 'Firsts'
PMH and it’s research arm, the Ontario Cancer Institute, have an enviable track record when it comes to ground-breaking work.  Below is a list of just some of the discoveries that have made headlines in the medical and scientific world.

1950s   Use of radiation to cure Hodgkin’s disease (Dr. Vera Peters)
     
1950s   Introduction of lumpectomy for breast cancer (Dr. Vera Peters)
     
1952   Use of cobalt radiotherapy units for cancer (Dr. Harold Johns)
     
1961   Discovery of blood forming stem cells enabling bone marrow transplants (Dr. Ernest McCulloch and Dr. James Till)
     
1984   First cloning of the T-cell receptor genes, significant in the field of immunology (Dr. Tak Mak)
     
1996   Chemotherapy treatment for hormone-resistant prostate cancer (Dr. Ian Tannock and Dr. Malcolm Moore)
     
2001   Discovery that a protein called Interleukin 13 fuels the growth of Hodgkin’s lymphoma (Dr. Tak Mak)
     
2002   Description of the role of IRAK-4, an immune molecule, critical for first-line defense against infections (Dr. Wen-Chen Yeh, Dr. Tak Mak and Dr. Pam Ohashi)
     
2002   Identifying gene clusters using micro-array technology that are involved in lung cancer (Drs. Denis Wigle, Igor Jurisica, Jim Woodgett, Shaf Keshavjee, Gail Darling, Frances Shepherd, and Ming Tsao)
     
2003   Demonstrating that dense breast tissue, a major risk factor in breast cancer, is mainly determined by genetic factors (Dr. Norman Boyd)
     
2003   Developing a method for detecting gene mutations that enhance care for families with retinoblastoma (Dr. Brenda Gallie)
     
2006   Cancer stem cells isolated in colon cancer (Dr. John Dick)
     
2007   Cancer stem cells isolated in head & neck cancers (Dr. Laurie Ailles)
     
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PMH is the first hospital to use digital mammography – an x-ray machine that takes a digital image of the breast – enabling earlier diagnosis of breast cancer with less radiation exposure.
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